Semaglutide CAS 910463-68-2 API

Kev cai noj qab haus huv
Semaglutide ua raws li cov tshuaj hormones ntuj GLP-1, uas yog tsim nyob rau hauv lub plab thiab ua lub luag haujlwm tseem ceeb hauv kev tswj kev qab los noj mov thiab kev noj zaub mov. Los ntawm kev ua kom lub GLP-1 receptors nyob rau hauv lub hlwb, semaglutide pab txo cov kev xav ntawm kev tshaib kev nqhis, ua rau txo qis calorie kom tsawg.

Ncua plab hnyuv
Semaglutide slows tus nqi ntawm cov zaub mov tawm hauv lub plab thiab nkag mus rau hauv cov hnyuv, ib tug txheej txheem hu ua qeeb gastric emptying. Qhov kev ncua ntev ntawm lub plab khoob no ua rau lub sijhawm ntev ntawm kev ua kom puv thiab satiety, ntxiv kom txo tau cov khoom noj.

Glucose-dependant insulin secretion
Semaglutide txhim kho qhov tso tawm ntawm cov tshuaj insulin hauv cov piam thaj hauv cov ntshav, txhais tau tias nws nce insulin tso tawm tsuas yog thaum cov ntshav qabzib nce siab. Qhov no yuav pab txhim kho cov ntshav qab zib thiab txo qis kev pheej hmoo ntawm hypoglycemia (cov ntshav qab zib tsawg).

Glucagon tiv thaiv
Glucagon yog ib yam tshuaj uas tsim los ntawm cov txiav thiab ua lub luag haujlwm tseem ceeb hauv kev tswj cov ntshav qab zib los ntawm kev txhawb nqa lub siab kom tso cov piam thaj mus rau hauv cov hlab ntsha. Los ntawm kev txo qis glucagon tso tawm, semaglutide pab txo qis cov ntshav qab zib hauv cov neeg mob ntshav qab zib. Los ntawm kev txo qis glucagon, semaglutide ntxiv pab tswj cov ntshav qab zib kom noj qab haus huv, uas yog qhov tshwj xeeb tshaj yog rau cov tib neeg uas muaj ntshav qab zib hom 2.

Kev siv hluav taws xob thiab lipid metabolism
Semaglutide tau pom tias yuav nce kev siv hluav taws xob thiab txhawb kev rog rog, ua rau txo qis hauv lub cev hnyav thiab txhim kho lub cev muaj pes tsawg leeg. Nws kuj tseem tuaj yeem muaj txiaj ntsig zoo rau lipid metabolism, ua rau muaj kev hloov pauv hauv cov roj cholesterol thiab triglycerides.

Qhov loj tshaj plaws kev soj ntsuam soj ntsuam kawm semaglutide nyob rau hauv cov neeg laus pom qhov nruab nrab qhov hnyav poob li ntawm 15% ntawm thawj lub cev hnyav tshaj 68 lub lis piam (yuav luag 16 lub hlis). Nyob rau tib lub sijhawm nyob rau hauv lwm txoj kev tshawb fawb, cov tub ntxhais hluas poob 15% ntawm lawv lub cev qhov hnyav ntawm qhov nruab nrab.

Muaj ob peb lub qhov ncauj yuag cov tshuaj muaj. Cov tshuaj noj qhov ncauj qhov hnyav yuav tsis tshua kim dua li cov kev txhaj tshuaj. Tab sis koj yuav tsis poob ntau npaum li qhov hnyav.

Phentermine:Phentermine (Adipex-P) yog ib qho nrov qhov ncauj qhov hnyav-tso tshuaj uas tau nyob ib ncig ntawm txij li thaum 1959. Nws tau pom zoo rau siv sij hawm luv luv (ob peb lub lis piam), thiab nws yog pheej yig. Txawm li cas los xij, nws muaj peev xwm txhim kho kev ua siab ntev rau cov tshuaj uas nws tsis ua haujlwm rau koj lawm. Ntxiv rau, nws yog cov tshuaj tswj tau.

Qsymia:Phentermine kuj muaj nyob rau hauv ua ke nrog topiramate nyob rau hauv lub hom npe Qsymia. Piv rau phentermine ib leeg, Qsymia tuaj yeem noj rau lub sijhawm ntev dua. Cov txiaj ntsig ntawm kev tshawb fawb tau pom tias qhov hnyav poob qis li ntawm 5% (ntawm koob tshuaj qis dua) mus txog 10% (ntawm koob tshuaj ntau dua).

Contrave:Contrave (bupropion / naltrexone) yog lwm cov tshuaj siv rau kev poob phaus. Ib txoj kev tshawb nrhiav pom tias cov neeg noj Contrave ua ke nrog kev noj haus thiab kev tawm dag zog poob qhov nruab nrab ntawm 9% ntawm lawv lub cev qhov hnyav tom qab 56 lub lis piam. Contrave kuj muaj ntau yam tshuaj sib cuam tshuam los xav txog.

Semaglutide rau kev poob phaus tau pom zoo siv rau cov neeg laus thiab cov menyuam yaus hnub nyoog 12 xyoos thiab laus dua raws li lawv lub cev qhov hnyav (BMI) thiab muaj qee yam mob.

Semaglutide (Wegovy) yog siv ntxiv rau kev noj haus thiab kev tawm dag zog rau kev tswj qhov hnyav mus ntev hauv:

Cov neeg laus uas rog rog (BMI Ntau dua lossis sib npaug li 30 kg / m2) lossis rog dhau (BMI Ntau dua lossis sib npaug li 27 kg / m2) nrog tsawg kawg ib qho hnyav hnyav xws li ntshav siab, ntshav qab zib hom 2, lossis cov roj (cholesterol) siab.
Cov tub ntxhais hluas hnub nyoog 12 xyoos thiab laus dua nrog qhov pib BMI ntawm lossis siab dua 95 feem pua ​​​​ntawm hnub nyoog thiab poj niam txiv neej (raws li cov kab kos loj hlob).
Semaglutide (Wegovy) kuj tau pom zoo Rau cov neeg laus, kom txo tau txoj kev pheej hmoo ntawm lub plawv nres, mob stroke thiab lub plawv muaj feem xyuam rau kev tuag ntawm cov neeg uas muaj kab mob plawv (lub plawv, hlab ntsha) nrog kev rog lossis rog.
Koj tuaj yeem kawm paub suav tus neeg laus BMI ntawm no. Kom koj tus menyuam tus kws kho menyuam yaus txiav txim siab lawv BMI feem pua ​​​​ntawm cov kab kos tam sim no.

Lwm cov tshuaj uas muaj semaglutide yog Ozempic (txhaj tshuaj) lossis Rybelsus (cov ntsiav tshuaj ntawm qhov ncauj). Cov hom no tsuas yog pom zoo los kho mob ntshav qab zib hom 2, suav nrog kev noj zaub mov thiab kev tawm dag zog, thiab tsis tau pom zoo tshwj xeeb rau kev poob phaus, tab sis tuaj yeem ua rau poob phaus.

Semaglutide (Ozempic) kuj tau txais kev pom zoo los pab tiv thaiv lub plawv thiab txo qhov kev pheej hmoo ntawm kev mob plawv, mob stroke lossis plawv plawv tuag rau cov neeg laus uas muaj ntshav qab zib hom 2 thiab mob plawv.

Koj tuaj yeem pom qee qhov poob phaus hauv 4 lub lis piam ntawm kev kho semaglutide, tab sis tag nrho cov txiaj ntsig tuaj yeem siv sijhawm ntau lub hlis. Tom qab 68 lub lis piam, cov neeg laus poob txog 35 lbs (15.9 kg) hauv kev tshawb fawb, qhov nruab nrab.

Koj tus kws kho mob yuav maj mam nce koj cov koob tshuaj thaum koj pib kho kom txo qis kev mob plab xws li xeev siab thiab raws plab. Nws feem ntau yuav siv sijhawm li 17 lub lis piam kom ncav cuag koj qhov kev kho zaum kawg ntawm semaglutide.

Kev tshawb fawb los ntawm cov chaw tsim khoom tshaj li 68 lub lis piam qhia tias, qhov nruab nrab, cov neeg laus siv semaglutide poob txog 35 lbs (15.9 kg), lossis txog 15% ntawm lawv lub cev hnyav. Hauv qhov sib piv, 31% ntawm cov neeg siv cov placebo (kev kho tsis muaj zog) poob txog 6 lbs (2.7 kg), lossis txog 2.5% ntawm lawv lub cev hnyav.

Hauv cov menyuam yaus hnub nyoog 12 xyoos thiab laus dua, semaglutide txo lawv lub cev qhov ntsuas qhov ntsuas (BMI) los ntawm 16.1% tom qab 68 lub lis piam piv rau qhov txo qis ntawm 0.6% hauv pawg placebo. Ntxiv rau, BMI raug txo tsawg kawg yog 5% hauv 77% ntawm cov menyuam tau txais semaglutide piv rau 20% tau txais cov placebo.

Peb ntseeg hais tias nyob rau hauv lub hwj chim ntawm kev tshawb fawb-rov qab kev kho mob, thiab Semaglutide tsis muaj kev zam. Cov tshuaj no tsom rau kev sib cuam tshuam ntawm cov tshuaj hormones, neurotransmitters, thiab neural circuits uas tswj kev qab los noj mov thiab cov metabolism.

Txhim khu kev noj qab haus huv thiab tswj kev noj qab haus huv
Receptors muaj ntau nyob rau hauv cov cheeb tsam ntawm lub hlwb lub luag hauj lwm rau qab los noj mov kev cai. Semaglutide activates cov receptors, ua rau kom muaj kev xav ntawm fullness thiab txo kev tshaib kev nqhis. Qhov no txhais tau hais tias koj muaj feem ntau yuav ua rau lub siab xav xaiv zaub mov thiab noj tsawg calories, ib qho tseem ceeb ntawm kev poob phaus.

Slowing Gastric Emptying
Semaglutide mus dhau qhov qab los noj mov los ntawm kev ua kom qeeb ntawm koj lub plab khoob. Qhov no ua rau muaj kev xav ntev ntev ntawm satiety tom qab noj mov, txwv koj txoj kev ntshaw thiab pab koj tiv thaiv kev xav kom overeat.

Modulating Reward Pathways
Semaglutide lub hwj chim txuas mus rau lub hlwb cov nqi zog cov chaw, uas yog lub luag hauj lwm rau cov pleasurable rhiab heev cuam tshuam nrog zaub mov. Los ntawm kev tsom mus rau cov neural circuits, Semaglutide pab dampen lub allure ntawm high-calorie, indulgent zaub mov, ua rau nws yooj yim rau lo rau koj cov kev npaj noj haus.

Daim ntawv thov ntawm semaglutide hauv cov neeg mob uas siab hematocrit thiab hemoglobin theem qhia ib txheej nuanced rau nws cov kev kho mob spectrum, tshwj xeeb tshaj yog xav txog qhov cuam tshuam ntawm cov kab mob hematological ntawm cov hlab plawv. Cov qib hematocrit thiab hemoglobin siab, qhia txog polycythemia, tuaj yeem ua rau cov ntshav viscosity nce ntxiv, ua rau muaj kev pheej hmoo ntawm thrombosis thiab vascular teeb meem.

Qhov cuam tshuam ntawm semaglutide ntawm qib hematocrit thiab hemoglobin yog lub ntsiab lus ntawm kev txaus siab, uas tau tsav los ntawm kev nkag siab tias cov kab mob metabolic tuaj yeem cuam tshuam rau ntau yam hematological tsis. Cov ntaub ntawv ua ntej qhia tias GLP-1 receptor agonists, suav nrog semaglutide, tuaj yeem muaj qhov tsis zoo lossis muaj txiaj ntsig zoo rau cov qib no. Txawm li cas los xij, cov txheej txheem hauv qab ntawm cov teebmeem no tsis tau piav qhia meej thiab lav kev tshawb nrhiav ntxiv. Cov lus piav qhia muaj peev xwm suav nrog semaglutide lub luag haujlwm hauv kev txhim kho kev tswj cov metabolism, uas tuaj yeem cuam tshuam rau erythropoiesis thiab cov ntshav liab hloov pauv.

Muab cov kev pheej hmoo ntawm cov hlab plawv cuam tshuam nrog cov qib hematocrit thiab hemoglobin siab, kev siv semaglutide hauv cov neeg no yuav tsum tau ua tib zoo xav. Nws suav nrog kev txheeb xyuas cov txiaj ntsig zoo ntawm kev txhim kho metabolic tiv thaiv qhov kev pheej hmoo ntawm cov ntshav viscosity thiab thrombosis. Cov kws kho mob yuav tsum tau txais txoj hauv kev ceev faj, suav nrog kev saib xyuas tsis tu ncua ntawm hematological tsis thiab cov tsos mob ntawm lub plawv thiab cov tsos mob, kom daws tau qhov teeb meem tsis zoo.

Kev tswj hwm ntawm cov neeg mob siab hematocrit thiab hemoglobin qib ntawm kev kho semaglutide kuj tseem hais txog qhov tseem ceeb ntawm txoj kev kho mob holistic. Cov tswv yim no yuav suav nrog kev cuam tshuam hauv kev ua neej, xws li kev haus dej thiab kev haus luam yeeb, thiab kev siv tshuaj aspirin lossis lwm yam tshuaj tiv thaiv kab mob hauv cov neeg mob uas muaj kev pheej hmoo siab ntawm cov hlab ntsha. Qhov kev txiav txim siab los pib lossis txuas ntxiv kev kho mob semaglutide hauv cov ntsiab lus no yuav tsum yog raws li kev soj ntsuam kev pheej hmoo-cov txiaj ntsig zoo, suav nrog tus neeg mob qhov kev pheej hmoo ntawm cov hlab plawv thiab qhov cuam tshuam ntawm kev txhim kho metabolic ntawm kev noj qab haus huv tag nrho.

Kev tshawb nrhiav ntawm semaglutide qhov cuam tshuam rau ntshav siab yog qhov chaw loj hlob tuaj, qhia txog cov tshuaj muaj peev xwm los muab cov txiaj ntsig ntawm cov hlab plawv tshaj nws qhov kev siv thawj zaug hauv ntshav qab zib thiab kev rog rog. Semaglutide cov txheej txheem ntawm kev ua, uas koom nrog txoj hauv kev receptor, tsis yog qhov tseem ceeb hauv kev tswj cov ntshav qabzib thiab qab los noj mov, tab sis kuj zoo li cuam tshuam rau cov hlab plawv hauv txoj hauv kev uas yuav cuam tshuam rau ntshav siab.

Cov kev tshawb fawb soj ntsuam tau pib teeb pom kev sib raug zoo ntawm semaglutide thiab ntshav siab, nrog cov ntaub ntawv qhia tias semaglutide tuaj yeem ua rau kev txhim kho hauv kev nyeem ntshav siab. Cov kev tshawb pom no yog qhov tseem ceeb, xav txog qhov muaj feem ntau ntawm cov ntshav siab ntawm cov neeg mob ntshav qab zib hom 2 thiab rog rog. Lub peev xwm rau semaglutide kom txo cov ntshav siab tuaj yeem sawv cev rau ob qho kev kho mob, hais txog kev tswj hwm cov metabolism thiab txo qis kev pheej hmoo ntawm cov hlab plawv ib txhij.

Cov txheej txheem los ntawm cov semaglutide tuaj yeem cuam tshuam cov ntshav siab ntau yam. Ib txoj kev xav qhia tias kev poob phaus vim yog semaglutide ua lub luag haujlwm tseem ceeb; Raws li cov neeg mob poob phaus, qhov kev nyuaj siab ntawm lawv cov hlab plawv txo qis, ua rau txo cov ntshav siab. Tsis tas li ntawd, semaglutide cov teebmeem ntawm insulin rhiab heev thiab cov ntshav qabzib tuaj yeem ua rau muaj kev txhim kho endothelial kev ua haujlwm, ntxiv rau kev tswj ntshav siab. Lub endothelium plays lub luag haujlwm tseem ceeb hauv kev noj qab haus huv ntawm cov hlab ntsha, thiab nws txoj haujlwm tsis zoo yog qhov paub txog kev mob ntshav siab.

Tsis tas li ntawd, qee qhov kev tshawb fawb qhia txog kev cuam tshuam ncaj qha ntawm receptor agonists ntawm cov hlab plawv, nrog rau kev txhim kho cov hlab ntsha thiab txo qis kev ua haujlwm ntawm lub paj hlwb, ob qho tib si tuaj yeem pab txo cov ntshav siab. Cov teebmeem no, ua ke nrog cov tshuaj tiv thaiv thiab tiv thaiv atheroprotective ntawm receptor agonists, underscore lub peev xwm ntawm cov hlab plawv cov txiaj ntsig ntawm semaglutide.

Lub tuam txhab tsom mus rau High potency polypeptide API / kev daws teeb meem, thiab muag polypeptide API / kev daws teeb meem thiab npaj cov kev pabcuam tsim khoom rau lub ntiaj teb ua lag luam. Lub tuam txhab npog tag nrho thaj tsam ntawm 55 mu, nrog rau tag nrho cov kev tsim kho thaj tsam li ntawm 70, 000 square meters, thiab tau tsim txog 800 square meters ntawm R & D center, 1, 000 square meters ntawm Qhov chaw tswj qhov zoo thiab 3,300 square meters ntawm GMP ntau lawm Rhiav.