Txoj Kev Kawm Tshiab: Semaglutide, 'Miracle Drug for Weight Los', tuaj yeem pab koj txo qhov mob hauv caug mob caj dab!

GLP-1 thiab mob caj dab hauv caug (OA)

GLP-1 receptors kuj muaj nyob rau hauv lub hauv caug pob qij txha, thiab cov kws tshawb fawb xav kom GLP-1 kho cov pob txha hauv caug thiab pob qij txha thaum poob phaus.

Cov nyhuv ntawm semaglutide rau mob hauv caug hauv cov neeg mob hauv caug mob caj dab (OA)

thiab rog

1.Lub hom phiaj: txhawm rau tshawb xyuas cov txiaj ntsig ntawm semaglutide ntawm lub hauv caug mob hauv cov neeg mob hauv caug mob caj dab (OA) thiab rog rog

2.Study tshuaj: Semaglutide (Wegovy), GLP-1 receptor agonist feem ntau siv los ua kom poob phaus.

3.Study Design: KAUJ RUAM 9 yog ib qho chaw sib koom ua ke, ntau lub teb chaws, Theem III kev kuaj mob.

Participant has a BMI of >30, kev kuaj mob ntawm lub hauv caug mob caj dab, hloov pauv hluav taws xob nruab nrab, thiab mob hauv caug. Lub hnub nyoog nruab nrab yog 56 xyoo, 81.6% yog poj niam, qhov hnyav nruab nrab yog 108.6 kg, qhov nruab nrab BMI yog 40.3, qhov nruab nrab lub duav ncig yog 118.7 cm, thiab lub hauv paus txhais tau tias WOMAC mob qhab nia yog 70.9.

Tag nrho ntawm 407 tus neeg koom tau raug xaiv thiab randomized kom tau txais semaglutide 2.4 mg lossis placebo subcutaneously ib lub lim tiam hauv qhov sib piv 2: 1 rau tag nrho 68 lub lis piam.

4. Kev tshawb nrhiav:

4.1.Knee mob: Siv WOMAC qhov kev ntsuas qhov mob, muaj 41.

4.2.Lose yuag: semaglutide Baseline txo 13.7%, pab pawg placebo poob 3.2%, semaglutide poob phaus tau kwv yees siab dua li cov placebo 10.5%.

4.3.Lub cev muaj nuj nqi: Los ntawm lub hauv paus rau lub lim tiam 68, WOMAC lub cev ua haujlwm tau raug txo qis dua hauv pawg semaglutide ntau dua li hauv pawg placebo, nrog qhov sib txawv tseem ceeb ntawm -14.9 ntsiab lus.

4.4.Analgesic siv: Tus nqi ntawm kev poob qis nrog cov tshuaj tua kab mob tau nrawm dua hauv pawg semaglutide dua li hauv pawg placebo, thiab qhov kev poob qis no tau khaws cia thoob plaws lub sijhawm kawm.

Tus kws tshawb fawb lub ntsiab lus ntawm

1. Dr. Enning Bliddal ntseeg tias GLP-1 receptor agonists tuaj yeem muaj kev cuam tshuam tshwj xeeb rau kev sib koom tes, tsis yog los ntawm kev poob phaus xwb.

2. Dr. Tonia Vincent ceeb toom tias thaum poob phaus tuaj yeem pab tswj qhov mob, xav paub ntau ntxiv txog cov tshuaj no.

 

cov ntaub ntawv siv:Semaglutide txhim kho hauv caug OA mob, lub cev muaj nuj nqi (medscape.com)

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