Txo cov cannabis dependence! Lwm daim ntawv pov thawj uas Semaglutide inhibits kev quav tshuaj

Txo cov cannabis dependence! Lwm daim ntawv pov thawj uas Semaglutide inhibits kev quav tshuaj

Marijuana yog cov tshuaj txhaum cai siv ntau tshaj plaws hauv Tebchaws Meskas, nrog ntau dua 45 lab tus neeg siv, ib feem peb ntawm cov neeg raug kev txom nyem los ntawm Marijuana Use Disorder (MUD). Marijuana Use Disorder (MUD) yog ib qho mob tshwm sim los ntawm kev quav tshuaj yeeb tshuaj, nrog kev siv dag zog raws li nws qhov tseem ceeb. Tam sim no, US Food and Drug Administration (FDA) tsis tau pom zoo ib yam tshuaj rau kev kho mob Marijuana Use Disorder.

**Semaglutide thiab Addiction**

Semaglutide yog cov tshuaj pom zoo rau kev kho mob ntshav qab zib hom 2 thiab tswj qhov hnyav. Nws ua haujlwm los ntawm kev ua raws li GLP-1 cov tshuaj hormones los txhawb cov tshuaj insulin secretion hauv cov lus teb rau kev noj zaub mov. Qhov no tsis tsuas yog pab tswj cov ntshav qab zib tab sis kuj txo qis qab los noj mov thiab noj zaub mov, pab kom poob phaus.

Nyob rau hauv xyoo tas los no, lub luag haujlwm ntawm semaglutide hauv inhibiting kev quav yeeb quav tshuaj tau txais kev txaus siab, suav nrog nws lub peev xwm los tiv thaiv kev quav yeeb quav tshuaj, nicotine, opioids, thiab khoom noj khoom haus, raws li tau pom los ntawm kev sim dhau los lossis cov neeg mob cov kev paub dhau los.

Txoj kev tshawb no tshiab tshawb nrhiav seb semaglutide tseem muaj kev cuam tshuam rau kev siv tshuaj maj. Cov kws sau ntawv tshawb fawb thiab tus thawj coj ntawm National Institute on Drug Abuse ntawm National Institutes of Health, Nora Volkow, piav qhia tias: "Peb ib txwm xav txog qhov kev cia siab ntawm txoj kev kho mob tshiab. ntawm semaglutide thiab lwm yam GLP-1 tshuaj hauv kev kho kev quav tshuaj."

** Kawm Subjects los ntawm 105.3 lab Obese lossis Hom 2 Cov Neeg Mob Ntshav Qab Zib Thoob Ntiaj Teb **

Txoj kev tshawb no tau siv qhov kev tsim qauv rov qab los, siv cov ntaub ntawv xov xwm hluav taws xob loj hauv kev noj qab haus huv los tshawb txog qhov muaj feem cuam tshuam ntawm semaglutide ntawm Marijuana Use Disorder. Nws suav nrog kwv yees li 105.3 lab tus neeg mob los ntawm 61 lub tsev kho mob loj nrog thaj chaw sib txawv thiab cov pej xeem keeb kwm thoob ntiaj teb.

Cov kws tshawb fawb tau tsom mus rau ob pawg tshwj xeeb: cov neeg mob kuaj pom tias muaj rog thiab cov neeg mob ntshav qab zib hom 2. Cov pab pawg no tau raug xaiv vim tias semaglutide yog siv rau kev tswj qhov hnyav thiab kev kho mob ntshav qab zib. Txoj kev tshawb no piv cov neeg mob kho nrog semaglutide rau cov neeg kho nrog lwm cov tshuaj uas tsis yog-GLP-1 (xws li bupropion thiab metformin) rau kev rog rog lossis ntshav qab zib.

**Semaglutide tuaj yeem txo qhov tshwm sim thiab rov tshwm sim ntawm Marijuana Siv Teebmeem **

Cov kws tshawb nrhiav pom tias piv rau cov tshuaj uas tsis yog-GLP-1 receptor agonist cov tshuaj, semaglutide cuam tshuam nrog kev txo qis ntawm kev tsim cov mob tshiab ntawm Marijuana Siv Teebmeem thiab txo qis qhov yuav rov qab los ntawm cov neeg uas muaj keeb kwm ntawm qhov teeb meem.

Rau cov neeg mob rog uas tsis tau kuaj pom yav dhau los ntawm Marijuana Siv Disorder, qhov tshwm sim ntawm Marijuana Siv Disorder nrog semaglutide yog {{0}}}.28%, piv rau 0.48% rau cov neeg kho nrog lwm tus. tshuaj tiv thaiv rog. Qhov kev tshawb pom no qhia tau hais tias kev pheej hmoo ntawm Marijuana Siv Disorder rau cov neeg siv semaglutide raug txo los ntawm 44%, thiab semaglutide tuaj yeem txo qhov tshwm sim ntawm tus kab mob. Ib yam li ntawd, hauv cov neeg mob rog yav dhau los tau kuaj pom tias Marijuana Siv Teebmeem, semaglutide tuaj yeem txo qhov rov tshwm sim ntawm tus kabmob. Tus nqi rov qab los ntawm Marijuana Siv Disorder hauv pawg semaglutide yog 13.0%, piv rau 20.4% hauv pawg tswj hwm, txhais tau hais tias qhov kev pheej hmoo nrog kev kho semaglutide raug txo los ntawm 38%, hais txog nws lub peev xwm los ua kev tiv thaiv kev kho mob.

Ntawm cov neeg mob uas muaj ntshav qab zib hom 2, semaglutide rov pom muaj kev tiv thaiv kev tiv thaiv tshiab thiab rov tshwm sim Marijuana Siv Disorder. Rau cov neeg mob ntshav qab zib hom 2 yam tsis tau kuaj pom yav dhau los ntawm Marijuana Use Disorder, qhov tshwm sim ntawm Marijuana Siv Disorder hauv pawg semaglutide (0.21%) tau qis dua piv rau cov uas tsis yog-GLP-1 receptor. pawg tshuaj agonist (0.48%).

Qhov ntawd yog hais tias, txawm hais tias rau cov neeg mob rog lossis cov neeg mob ntshav qab zib, piv rau cov tshuaj uas tsis yog GLP-1, semaglutide tuaj yeem txo qhov tshwm sim thiab rov tshwm sim ntawm Marijuana Siv Teebmeem.

** Yav tom ntej Prospects **

Txawm li cas los xij, txawm tias cov txiaj ntsig tau zoo, txoj kev tshawb no muaj qee qhov kev txwv uas yuav tsum tau sau tseg. Nws qhov xwm txheej rov qab los thiab kev cia siab ntawm cov ntaub ntawv kho mob uas twb muaj lawm txhais tau hais tias kev ua txhaum cai tsis tuaj yeem tsim. Cov kws tshawb fawb tau hais tias cov kev tshawb fawb yav tom ntej yuav tsum suav nrog kev soj ntsuam ntev dua thiab cov kev tswj hwm cov placebo los txheeb xyuas thiab nthuav dav rau cov kev tshawb pom no. Txhawm rau txhawb nqa kev kho mob ntawm semaglutide, randomized soj ntsuam kev sim yog tsim nyog.

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