Kev Xaiv Tawm Tshiab rau cov ntshav qab zib tswj: Daim ntawv thov ntawm Tirzepatide hauv kev kho mob ntshav qab zib hom 2

Tirzepatide yog av qeeg los tiv thaiv tshuaj tiv thaiv tshuaj, ua lub ntiaj teb ua ntej thiab tsuas yog kev xaiv kho rau cov neeg mob ntshav qab zib hom 2 (t2dm). Cov tshuaj no tsim nyog rau cov neeg mob T2DM tseem tsis tau tswj hwm txawm tias kev siv dag zog thiab kev tawm dag zog nrog metformin thiab / lossis sulfonyhluras. Qhov tsis sib xws ntawm tirzepatide lus dag nyob rau hauv nws cov qauv molecular; Nws yog cov amino acids diacid ntu uas tuaj yeem khi rau albumin thiab txuas ntxiv nws ib nrab-lub neej, tso cai rau ib zaug noj ib zaug. Ntxiv mus, Tirzepatide muaj kev xaiv siab rau tib neeg gip thiab gip}}} Cov khoom noj khoom haus, thiab cov kev ua si qis dua ntawm lub glp -1 dua. Qhov no dual agonism tau pab txhim kho cov ntshav qab zib ntshav, muab cov phiaj xwm kho kom zoo dua rau cov neeg mob ntshav qab zib nrog hom 2 ntshav qab zib.

Kev ua tau zoo ntawm Tirzepatide yog txhawb los ntawm ntau qhov kev tshawb fawb hauv kev kuaj mob. Piv txwv li, lub surpass series ntawm cov kev tshawb fawb tau pom zoo tshwm sim hauv kev kho mob ntshav qab zib. Raws li lub surpass {{{0}}}}}}} theem kev kawm tau muaj hemoglobin A1c (HBA1C) qis dua 7%; Ntau tshaj 52% ntawm cov neeg mob muaj qib HBA1C hauv qab no 5.7%, piv rau tsuas yog 1% ntawm cov neeg mob hauv cov pab pawg placebo. Tsis tas li ntawd, cov kev kawm surpass-AP-combo Cov txiaj ntsig kev tshawb fawb no tau lees paub qhov tseem ceeb ntawm Tirzepatide hauv kev txhim kho cov ntshav qab zib los tswj cov neeg mob hom 2 cov ntshav qab zib.

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