Muaj peev xwm yav tom ntej Indications rau Semaglutide

Muaj peev xwm yav tom ntej Indications rau Semaglutide

Non-alcoholic Steatohepatitis (NASH) Thaum GLP-1 khi rau daim siab cell receptors, nws tuaj yeem txo daim siab steatosis, hepatocyte puas, thiab cov piam thaj tso zis. Hauv NASH, nws tuaj yeem txo cov lus teb inflammatory thiab fibrosis ntawm hepatocytes. Semaglutide tau pom cov txiaj ntsig zoo hauv theem 2 kev sim tshuaj rau kev kho mob NASH, nrog 66.7% ntawm cov neeg mob hauv pawg koob tshuaj ntau tshaj plaws tau tshem tawm cov tsos mob NASH; nyob rau hauv cov nqe lus ntawm kev txhim kho daim siab fibrosis, tsuas yog 5.8% ntawm cov neeg mob nyob rau hauv lub siab tshaj plaws koob tshuaj semaglutide pab pawg neeg kho mob pom muaj kev loj hlob ntawm daim siab fibrosis (piv rau 21.4% nyob rau hauv cov placebo pab pawg neeg). Tam sim no, theem 3 thoob ntiaj teb multicenter kev sim tshuaj ntsuam xyuas ntawm semaglutide rau NASH tau pib hauv Suav teb, uas xav tias yuav muab txoj hauv kev kho tshiab rau NASH.

Cov Kab Mob Neurological GLP-1 txoj kev taw qhia tuaj yeem txhim kho cov txheej txheem kev txawj ntse, txhawb kev tiv thaiv kab mob, thiab tso tawm cov tshuaj neurotransmitters. Yog li ntawd, GLP-1 receptor yog suav tias yog lub hom phiaj zoo rau kev tshawb nrhiav tshuaj nrog kev tiv thaiv kab mob zoo dua thiab muaj peev xwm txhim kho kev txawj ntse. Kuj tseem muaj kev tshawb fawb qhia tias GLP-1 receptor agonists (GLP-1RAs) yuav muaj txiaj ntsig zoo hauv kev kho mob qaug dab peg thiab tuaj yeem txo cov cell puas los ntawm cerebral ischemia. Yog li, semaglutide muaj peev xwm muaj txiaj ntsig hauv kev kho mob ntawm ntau yam kab mob paj hlwb xws li Alzheimer's disease thiab Parkinson's disease, thiab xav tau kev tshawb fawb ntxiv.

Polycystic Ovary Syndrome (PCOS) Meta-analyses tau pom tias GLP-1RAs tuaj yeem txo qhov hnyav, qib testosterone, thiab txhim kho ovulation hauv cov neeg mob rog PCOS. Piv nrog rau metformin, GLP-1RAs tau raug pov thawj los txhim kho PCOS cov xwm txheej xws li oligomenorrhea, rog rog, insulin tsis kam, thiab kev tso tshuaj hormonal ntau dua. Qee cov kev tshawb fawb kuj tau qhia tias kev kho mob ua ke nrog GLP-1RAs thiab metformin yog qhov zoo tshaj rau metformin ib leeg hauv kev nce tus nqi ntawm cev xeeb tub thiab cev xeeb tub hauv vitro. Tam sim no tsis muaj kev soj ntsuam loj ntawm semaglutide rau kev kho PCOS, thiab nws lub luag haujlwm pathophysiological thiab cov nqi kho mob hauv PCOS tseem tab tom nrhiav thiab tshawb nrhiav.

Kev Tshawb Fawb Osteoporosis tau pom tias GLP-1RAs tuaj yeem ua rau cov pob txha loj, trabecular thiab cortical thickness, txhim khu cov pob txha muaj zog, thiab cuam tshuam rau collagen, ua rau lawv cov kev tswj hwm ntawm cov pob txha metabolism los ntawm kev cuam tshuam cov tshuaj hormones tso tawm los ntawm osteocytes, thiab suav hais tias muaj qhov zoo. Daim ntawv thov kev cia siab rau hauv ntshav qab zib osteoporosis, senile osteoporosis, postmenopausal osteoporosis, thiab glucocorticoid-induced osteoporosis. Cov kev tshawb fawb qhia tias sib txawv GLP-1RAs tej zaum yuav muaj cov txheej txheem molecular sib txawv, yog li qhov cuam tshuam ntawm semaglutide ntawm cov pob txha metabolism yuav tsum tau tshawb fawb soj ntsuam ntxiv kom paub meej.

Cov kab mob ntawm daim tawv nqaij GLP-1 txhawb nqa kev tsiv teb tsaws ntawm keratinocytes los ntawm kev ua kom txoj hauv kev PI3K/AKT, ua kom cov tawv nqaij microvascular perfusion, uas muaj txiaj ntsig zoo rau kev kho qhov txhab; GLP-1 tuaj yeem koom ncaj qha rau hauv lub cev tiv thaiv kab mob ntawm cov kab mob dermal thiab txo cov kev qhia ntawm δT hlwb thiab tso tawm ntawm IL-17, yog li txo qhov kev mob ntawm cov kab mob dermal thiab txo cov mob psoriasis. Kev txhim kho cov kab mob ntawm daim tawv nqaij los ntawm semaglutide tseem xav tau kev tshawb nrhiav ntxiv. Ua raws li kev kho mob ntawm T2DM, kev siv cov tshuaj semaglutide ib zaug ib lub lim tiam rau kev kho mob lwm yam kab mob tau cog lus rau yav tom ntej.

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