Tirzepatide Qhia Kev cog lus hauv OSA Kev Kho Mob

Cov kev tshawb fawb tshiab tshaj plaws qhia tau hais tias Tirzepatide tau ua tiav cov txiaj ntsig zoo hauv Phase III SURMOUNT-OSA kev soj ntsuam kuaj mob rau kev kho mob ntawm qhov nruab nrab mus rau qhov hnyav obstructive pw tsaug zog apnea (OSA). Piv nrog rau cov placebo, Tirzepatide txo qis qhov apnea-hypopnea index (AHI) ntawm cov kev kawm, ua tiav cov ntsiab lus kawg. AHI sau cov naj npawb ntawm cov sij hawm ib teev ntawm kev pw tsaug zog uas cov neeg mob ua pa yog txwv los yog thaiv tag nrho, thiab yog siv los ntsuas qhov hnyav ntawm OSA thiab cov txiaj ntsig ntawm kev kho mob. Hauv txoj kev tshawb no, AHI ntawm pawg Tirzepatide tau txo qis los ntawm qhov nruab nrab ntawm 62.8%, uas yog, tus naj npawb ntawm cov sij hawm hauv ib teev ntawm kev pw tsaug zog uas ua tsis taus pa raug txwv lossis tag nrho raug txo los ntawm 30 zaug.

Tsis tas li ntawd, ntawm cov ntsiab lus tseem ceeb thib ob, 43. Tus qauv no yog txhais los ntawm AHI thiab Epworth Sleepiness Scale (ESS) kev ntsuas, qhov "kev tshem tawm kab mob" txhais tau hais tias tus neeg kawm AHI tsawg dua 5 zaug hauv ib teev, lossis AHI nyob nruab nrab ntawm 5-14 zaug hauv ib teev thiab Epworth Sleepiness Scale (ESS) cov qhab nia tsawg dua lossis sib npaug rau 10.

Cov ntaub ntawv no qhia tias Tirzepatide tsis tsuas yog qhia tau tias muaj peev xwm poob phaus tab sis kuj tseem tuaj yeem muab cov kev kho mob tshiab rau cov neeg mob uas muaj mob hnyav rau OSA. Kev tshawb fawb ua tiav ntawm Tirzepatide tuaj yeem txhais tau tias nws yuav qhib kev lag luam tshiab hauv kev kho mob OSA, tshwj xeeb tshaj yog rau cov neeg tsis tuaj yeem lossis tsis kam siv txoj kev kho cua zoo (PAP).

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