Tirzepatide vs Semaglutide

Txawm hais tias Tirzepatide thiab Semaglutide yogme ntsis cov tshuaj sib txawv, lawv nyob rau hauv tib chav kawm ntawm cov tshuaj thiab yuav luag tib yam cuam tshuam rau lub cev.

Tirzepatide thiab Semaglutide yog ob qho tib si cais ua GLP-1 (glucagon-zoo li peptide-1) receptor agonists thiab feem ntau tau siv los kho mob ntshav qab zib hom 2 yav dhau los. Tsis ntev los no txawm li cas los xij, cov tshuaj no tau raug siv thiab tshuaj xyuas rau kev kho mob rog thiab ob leeg tau pom tias muaj txiaj ntsig zoo rau kev tswj qhov hnyav.

Tirzepatide vs. Semaglutide ua haujlwm li cas rau kev poob phaus?

Tirzepatide thiab Semaglutide ob leeg ua haujlwm los ntawm kev ua raws li cov tshuaj hormones hauv plab. Semaglutide thiab Tirzepatide ob leeg ua raws li GLP-1 cov tshuaj hormones, tab sis Tirzepatide mimics GIP (glucose-dependent insulinotropic polypeptide) cov tshuaj hormones thiab, ua rau nws yogob agonist. GLP-1 thiab GIP cov tshuaj hormones koom nrog hauv cov haujlwm zoo sib xws ntawm lub cev uas tswj cov ntshav qab zib, xa cov cim qab los noj mov / tshaib plab rau lub hlwb, thiab cuam tshuam rau kev zom zaub mov.²

Thaum noj cov tshuaj no koj yuav muaj kev paub:

Txo kev tshaib plab / qab los noj mov

Txhim kho satiety (zoo siab ntev nrog cov me me)

Txo cov zaub mov cravings

Tsawg tag nrho lub hlwb tsom rau zaub mov

Tag nrho cov xwm txheej no ua rau nws yooj yim dua rau kev ua raws li caloric deficit uas yog qhov tseem ceeb rau kev poob phaus.

Puas yog Tirzepatide thiab Semaglutide FDA pom zoo rau kev poob phaus?

Semaglutide yog FDA pom zoo rau kev poob phaus raws li lub npe Wegovy®. Wegovy® yog thawj zaug ib lub lim tiam ntawm cov tshuaj hauv GLP-1 cov tshuaj kom pom zoo rau kev poob phaus. Ozempic®, lwm lub npe ntawm Semaglutide, yog FDA pom zoo rau hom 2 mob ntshav qab zib. Ozempic® feem ntau raug sau tseg rau kev poob phaus vim nws muaj tib yam khoom xyaw xws li Wegovy®, -Semaglutide.

Tirzepatide tau pom zoo rau kev poob phaus raws li lub npe, Zepbound®. Hauv kev sim tshuaj Tirzepatide tau pom tias yog ib qho tshuaj txo qhov hnyav uas tsis yog pab kom poob phaus xwb tab sis txhim kho cov txiaj ntsig cardiometabolic rau cov neeg koom. Tirzepatide kuj yog FDA pom zoo rau hom 2 mob ntshav qab zib hom 2 raws li lub npe, Mounjaro®. Zoo li Ozempic®, Mounjaro® feem ntau tau sau npe tawm rau kev poob phaus vim nws muaj tib yam khoom xyaw xws li Zepbound® - Tirzepatide.

Puas yog Tirzepatide lossis Semaglutide zoo dua rau kev poob phaus?

Ob qho tshuaj Tirzepatide thiab Semaglutide muaj txiaj ntsig zoo rau kev poob phaus raws li lawv cov kev sim tshuaj ntsuam xyuas nrog cov neeg koom nrog poob qhov nruab nrab ntawm 15-21% ntawm lawv lub cev qhov hnyav.

Thaum tsis muaj kev tshawb fawb luam tawmtseemuas ncaj qha sib piv ob cov tshuaj rau kev poob phaus, peb tuaj yeem txheeb xyuas thiab sib piv cov ntaub ntawv los ntawm cov ntaub ntawv tshawb fawb luam tawm rau txhua yam tshuaj.

Semaglutide Weight Loss Clinical Trial Results (STEP 1)

Semaglutide KAUJ RUAM 1 kev soj ntsuam kuaj mob tau ua raws li 1,961 tus neeg koom nrog BMI 30+, lossis BMI 27+ nrog ib lossis ntau qhov teeb meem kev noj qab haus huv (xws li kub siab, kab mob plawv, thiab lwm yam) rau 68 lub lis piam. Cov neeg koom nrog tau raug muab tso rau Semaglutide lossis cov placebo, ntxiv rau kev cuam tshuam kev ua neej ntawm kev noj zaub mov thiab kev tawm dag zog. ⁵

Semaglutide Nruab Nrab Cov Neeg Koom Tes Poob Qhov hnyav:

Semaglutide: 14.9% lub cev hnyav

Cov placebo: 2.4% lub cev hnyav

Tirzepatide Poob Qhov Kev Ntsuam Xyuas Kev Tshawb Fawb Kev Tshawb Fawb (SUMOUNT 1)

Tirzepatide SURMOUNT 1 qhov kev sim tshuaj tau ua raws li 2,539 tus neeg koom nrog BMI 30+, lossis BMI 27+ nrog ib lossis ntau qhov teeb meem txog kev noj qab haus huv (xws li kub siab, kab mob plawv, thiab lwm yam) rau 72 lub lis piam. Cov neeg koom nrog tau raug muab tso rau Tirzepatide 5 mg, 10 mg, 15 mg, lossis placebo, ntxiv rau kev cuam tshuam kev noj qab haus huv ntawm kev noj haus thiab kev tawm dag zog.⁶

Tirzepatide Nruab Nrab Cov Neeg Koom Tes Poob Qhov hnyav:

Tirzepatide (15 mg): 20.9% lub cev hnyav

Tirzepatide (10 mg): 19.5% lub cev hnyav

Tirzepatide (5 mg): 15% lub cev hnyav

Placebo: 3.1% lub cev hnyav

Raws li pom nyob rau hauv cov ntaub ntawv kawm muaj nyob rau saum toj no, Semaglutide thiab Tirzepatide muaj txiaj ntsig zoo rau kev poob phaus thaum piv rau cov placebo.; txawm li cas los xij,Tirzepatide tuaj yeem ua tau zoo dua li Semaglutide.*

* Txoj kev tshawb fawb tshiab los sib piv ob qhov ncaj qha tam sim no tab tom ua tiav (Clinical Trial: NCT05822830).

Kuv yuav tsum poob phaus npaum li cas ntawm Tirzepatide vs. Semaglutide?

Nws nyob ntawm. Tus nqi ntawm kev poob phaus thiab qhov hnyav poob yuav txawv nyob ntawm seb koj lub cev teb li cas rau cov tshuaj, ntau npaum li cas, kev ua raws li kev hloov hauv kev ua neej, thiab cov yam ntxwv lom.

Raws li kev sim tshuaj ntsuam xyuas tau hais los saum toj no, cov neeg mob noj Semaglutide poob qhov nruab nrab ntawm 15% ntawm lawv lub cev qhov hnyav thaum cov neeg mob noj Tirzepatide poob qhov nruab nrab ntawm 20% ntawm lawv lub cev hnyav. Piv txwv li, qhov ntawd txhais tau hais tias ib tus neeg hnyav 200 phaus yuav poob kwv yees li 30 phaus noj Semaglutide, piv rau kwv yees li 40 phaus noj Tirzepatide.

Cov kev mob tshwm sim ntawm Tirzepatide vs. Semaglutide yog dab tsi?

Cov teebmeem tshwm sim ntawm Tirzepatide thiab Semaglutide yuav luag zoo ib yam. Cov kev mob tshwm sim feem ntau ntawm Tirzepatide thiab Semaglutide muaj xws li xeev siab, cem quav, reflux / plab zom mov, ntuav, thiab raws plab. Rau ob qho tshuaj, feem ntau ntawm cov kev mob tshwm sim tshwm sim thaum noj tshuaj ntau ntxiv thiab ua kom zoo dua lub sijhawm.^5,6

Leej twg tuaj yeem noj Tirzepatide lossis Semaglutide?

Cov neeg laus rog rog lossis cov neeg rog rog tsawg kawg ib qho teeb meem txog kev noj qab haus huv uas tsis yog hom 2 mob ntshav qab zib thiab cov neeg laus uas muaj ntshav qab zib hom 2 tuaj yeem tsim nyog rau Semaglutide thiab / lossis Tirzepatide.

Leej twg yuav tsum tsis txhob noj Tirzepatide lossis Semaglutide?

Yog tias koj muaj tus kheej lossis tsev neeg keeb kwm ntawm medullary thyroid carcinoma (MTC) lossis muaj ntau yam endocrine neoplasia syndrome type 2 (MEN 2)

Yog tias koj tau paub qhov mob hnyav heev rau Tirzepatide lossis ib qho ntawm cov khoom xyaw hauv cov npe, Mounjaro® lossis Zepbound®.

Yog tias koj tau muaj kev tsis haum tshuaj loj rau Semaglutide lossis ib qho ntawm cov khoom xyaw hauv cov npe, Wegovy® lossis Ozempic®

Kuv yuav ua li cas thiaj tau txais daim ntawv tshuaj Tirzepatide lossis Semaglutide?

Yog tias koj ua tau raws li BMI cov cai ntawm 30+, lossis, 27+ nrog ib lossis ntau qhov teeb meem txog kev noj qab haus huv koj tuaj yeem tsim nyog rau Semaglutide thiab/los yog Tirzepatide.